Background Estimation in a Gravitational Wave Experiment

The problem to estimate the background due to accidental coincidences in the search for coincidences in gravitational wave experiments is discussed. The use of delayed coincidences obtained by orderly shifting the event times of one of the two detectors is shown to be the most correctComment: Latex file. 6 pages, 3 figures. Submitted to the proceeding of the 3 GWDAW workshop (Rome, dic 1999) (International journal of Modern physics D

Coherent search of continuous gravitational wave signals: extension of the 5-vectors method to a network of detectors

We describe the extension to multiple datasets of a coherent method for the search of continuous gravitational wave signals, based on the computation of 5-vectors. In particular, we show how to coherently combine different datasets belonging to the same detector or to different detectors. In the latter case the coherent combination is the way to have the maximum increase in signal-to-noise ratio. If the datasets belong to the same detector the advantage comes mainly from the properties of a quantity called {\it coherence} which is helpful (in both cases, in fact) in rejecting false candidates. The method has been tested searching for simulated signals injected in Gaussian noise and the results of the simulations are discussed.Comment: 9 pages, 2 figures. Journal of Physics: Conference Series, in pres

A method for narrow-band searches of continuous gravitational wave signals

Targeted searches of continuous waves from spinning neutron stars normally assume that the frequency of the gravitational wave signal is at a given known ratio with respect to the rotational frequency of the source, e.g. twice for an asymmetric neutron star rotating around a principal axis of inertia. In fact this assumption may well be invalid if, for instance, the gravitational wave signal is due to a solid core rotating at a slightly different rate with respect to the star crust. In this paper we present a method for {\it narrow-band} searches of continuous gravitational wave signals from known pulsars in the data of interferometric detectors. This method assumes source position is known to high accuracy, while a small frequency and spin-down range around the electromagnetic-inferred values is explored. Barycentric and spin-down corrections are done with an efficient time-domain procedure. Sensitivity and computational efficiency estimates are given and results of tests done using simulated data are also discussed.Comment: 13 pages; 6 figures; accepted in PR

Novel directed search strategy to detect continuous gravitational waves from neutron stars in low- and high-eccentricity binary systems

We describe a novel, very fast and robust, directed search incoherent method for periodic gravitational waves (GWs) from neutron stars in binary systems. As directed search, we assume the source sky position to be known with enough accuracy, but all other parameters are supposed to be unknown. We exploit the frequency-modulation due to source orbital motion to unveil the signal signature by commencing from a collection of time and frequency peaks. We validate our pipeline adding 131 artificial continuous GW signals from pulsars in binary systems to simulated detector Gaussian noise, characterized by a power spectral density Sh = 4x10^-24 Hz^-1/2 in the frequency interval [70, 200] Hz, which is overall commensurate with the advanced detector design sensitivities. The pipeline detected 128 signals, and the weakest signal injected and detected has a GW strain amplitude of ~10^-24, assuming one month of gapless data collected by a single advanced detector. We also provide sensitivity estimations, which show that, for a single- detector data covering one month of observation time, depending on the source orbital Doppler modulation, we can detect signals with an amplitude of ~7x10^-25. By using three detectors, and one year of data, we would easily gain more than a factor 3 in sensitivity, translating into being able to detect weaker signals. We also discuss the parameter estimate proficiency of our method, as well as computational budget, which is extremely cheap. In fact, sifting one month of single-detector data and 131 Hz-wide frequency range takes roughly 2.4 CPU hours. Due to the high computational speed, the current procedure can be readily applied in ally-sky schemes, sieving in parallel as many sky positions as permitted by the available computational power

HIV-Reverse Transcriptase Inhibition: Inclusion of Ligand-Induced Fit by Cross-Docking Studies

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), a definitive role in the treatment of HIV-1 infections. Since the appearance of HEPT and TIBO, more than 30 structurally different classes of compounds have been reported as NNRTIs, which are specific inhibitors of HIV-1 replication, targeting the HIV-1 reverse transcriptase (RT). Nevirapine and delavirdine are the first formally licensed for clinical use, and others have been licensed afterward, while several are in preclinical or clinical development. The NNRTIs interact with a specific site of HIV-1 RT (nonnucleoside binding site, NNBS) that is close to, but distinct from, the NRTI binding site. In this work we report the application of the Autodock program assessing its usability through reproduction of 41 NNRTI experimental bound conformations. Moreover, cross-docking experiments on the wild-type and mutated RT forms were conducted to take into account the enzyme flexibility as a valuable tool for structure-based drug design (SBDD) studies and to gain insight on the mode of action of new anti-HIV agents active against both wild-type and resistant strains

A method to search for long duration gravitational wave transients from isolated neutron stars using the generalized FrequencyHough

We describe a method to detect gravitational waves lasting $O(hours-days)$ emitted by young, isolated neutron stars, such as those that could form after a supernova or a binary neutron star merger, using advanced LIGO/Virgo data. The method is based on a generalization of the FrequencyHough (FH), a pipeline that performs hierarchical searches for continuous gravitational waves by mapping points in the time/frequency plane of the detector to lines in the frequency/spindown plane of the source. We show that signals whose spindowns are related to their frequencies by a power law can be transformed to coordinates where the behavior of these signals is always linear, and can therefore be searched for by the FH. We estimate the sensitivity of our search across different braking indices, and describe the portion of the parameter space we could explore in a search using varying fast Fourier Transform (FFT) lengths.Comment: 15 figure

Asteroseismology of solar-type stars with Kepler: III. Ground-based data

peer reviewedWe report on the ground-based follow-up program of spectroscopic and photometric observations of solar-like asteroseismic targets for the Kepler space mission. These stars constitute a large group of more than a thousand objects which are the subject of an intensive study by the Kepler Asteroseismic Science Consortium Working Group 1 (KASC WG-1). In the current work we will discuss the methods we use to determine the fundamental stellar atmospheric parameters using high-quality stellar spectra. These provide essential constraints for the asteroseismic modelling and make it possible to verify the parameters in the Kepler Input Catalogue (KIC)